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KMID : 0616120170480040304
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Korean Journal of Pharmacognosy
2017 Volume.48 No. 4 p.304 ~ p.313
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Anti-dementia Effects of Cornus officinalis S. et Z. extract on the Scopolamine Induced Dementia in Mouse
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Sohn Gee-Ho
Kim Jeong-Suk
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Abstract
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These days, as the average span of population’s life increases, the number patients of dementia also increases. But Research on Korean medicine is stilled limited. The research evaluates the effect of the extract from Cornus officinalis S.et Z on cognitive impairment induced by scopolamine in mice. The mice were randomly divided into five groups of ten mice. The normal group was treated with only 0.9% saline. The control group was treated with scopolamine (5 mg/kg, i.p.). The positive control group was treated with tacrin. The C100, 200 group was treated with C. officinalis extracts 100, 200 mg/kg. Memoryrelated behaviors were evaluated using a morris water maze and a passive avoidance test. Protein levels of BDNF, p-CREB (ser133), immunohistochemistry staining, and cholinergic activities were measured in brain tissue. The effects of C. officinalis extract significantly increased acetylcholine concentration and decreased acetylcholinesterase activity. The C. officinalis extract affected memory formation. Also, to confirm expression of protein BDNF, p-CREB (ser133) in the hippocampus, the researchers observed that immunohistochemistry and western blot increased in C. officinalis extract. These results suggest that C. officinalis provides a significant neuroprotective effect against scopolamine-induced cholinergic system and cognitive impairment.
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KEYWORD
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Dementia, Cornus officinalis S. et Z, Scopolamine
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